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KMID : 0856920140170010027
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Journal of Hospice and Palliative Care
2014 Volume.17 No. 1 p.27 ~ p.33
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Vitamin D Deficiency and Related Factors in Patients at a Hospice
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Moon Kyoung-Hwan
Ahn Hee-Kyung
Ahn Hong-Yup
Choi Sun-Young
Hwang In-Cheol
Choi Youn-Seon
Yeom Chang-Hwan
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Abstract
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Purpose: Although vitamin D deficiency is more commonly found in cancer patient than in non-cancer patients, there have been little data regarding the prevalence of vitamin D deficiency in cancer patients at the very end of life. We examined vitamin D deficiency in terminally ill cancer patients and related factors.
Methods: This study was based on a retrospective chart review of 133 patients in a hospice ward. We collected data regarding age, sex, serum 25-hydroxyvitamin D level, cancer type, physical performance, current medications and various laboratory findings. We investigated factors related to serum vitamin D levels after multivariate adjustment for potential confounders. Serum 25-hydroxyvitamin D＜20 ng/mL was considered deficient and <10 ng/mL severely deficient.
Results: Ninety-five percent of the patients were serum vitamin D deficient. Severe vitamin D deficiency was more common in male patients, non-lung cancer patients, H2 blocker users and non-anticonvulsant users. Elevated levels of serum alanine aminotransferase (ALT) were also associated with low serum vitamin D levels. Multiple regression analysis showed that severe vitamin D deficiency was associated with male gender (aOR 3.82, 95% CI: 1.50∼9.72, P=0.005), H2 blocker users (aOR 3.94, 95% CI: 1.61∼9.65, P=0.003) and elevated serum ALT levels (aOR 4.52, 95% CI: 1.35∼15.19, P=0.015).
Conclusion: Vitamin D deficiency was highly prevalent among terminally ill cancer patients. Severe vitamin D deficiency was more common in male patients, H2 blocker users, and patients with elevated ALT levels.
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KEYWORD
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Vitamin D deficiency, Hospices, Neoplasms
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